Introducing our Nature paper on a novel nano-immunotherapy scheme for atherosclerosis

We are excited to share with you our Nature in Biomedical Engineering article on the multi-parametric evaluation of a novel nano-immunotherapy scheme targeting atherosclerosis disease. The proposed methodology moderates CD40–CD40 ligand signalling in monocytes and macrophages of atherosclerotic plaques by blocking the interaction between CD40 and tumor necrosis factor receptor-associated factor 6 (TRAF6).

The accumulation of monocytes and macrophages in atherosclerosis has been associated with destabilization and rupture of plaque which can lead to acute cardiac events. Therefore, intervening in macrophage dynamics can be an efficacious therapeutic strategy in cardiovascular diseases. Indeed, our study demonstrated that a 1-week treatment regimen achieved significant anti-inflammatory effects in mice and non-human primates, due to the impaired migration capacity of monocytes.

We are very proud to have actively participated in this wonderful journey together with more than 30 researchers in 11 departments, across three countries. If you are interested in further details, please have a look at Dr Lameijer’s news article or read our original manuscript.

Thank you!


Parametric PET imaging is now a product!

Very proud that our early work on whole-body parametric PET imaging inspired important industry vectors to translate this technology into their clinical scanner systems. We first paved the way back in 2001 at Rahmim Lab and great collaborators joined us on the way. With the support of the industry (FlowMotion MultiParametric PET by Siemens) we are now optimistic that the clinical PET community will utilize dynamic whole-body PET acquisition and direct 4D reconstruction technology to benefit from the high quantification capabilities complementing the currently established static SUV PET imaging.

Dynamic and multi-parametric whole-body PET imaging has arrived in clinic and it is readily available NOW.

Thank you!

Finally, there is a vendor product (FlowMotion Multiparametric PET by Siemens) that enables dynamic whole-body PET including parametric imaging. This is very rewarding given that our group was the earliest to propose and work on this framework, including close collaboration with Siemens. This is clearly an enabling technology, and it remains to be seen whether […]  via Rahmim Lab