As as a postdoctoral research fellow in the Translational and Molecular Imaging Institute in the Icahn School Medicine at Mt Sinai, NY, I am leading or co-leading a number of research projects in nuclear medical imaging, mainly in the area of cardiovascular PET/MR dynamic acquisition, clinical imaging protocol optimization, novel tracers kinetic modeling, parameter estimation methods, motion compensation techniques, and cluster-based image reconstruction priors. My principal application field involves truly quantitative PET/MR imaging studies for whole-body cardiovascular and oncology studies.

Our projects target both basic research and clinical translation orientation thanks to the highly integrated medical imaging research environment established at Translational and Molecular Imaging Institute. Therefore our research involves the design, development and validation of clinically adoptable PET imaging frameworks supported by efficient and robust image reconstruction and analysis algorithms. Our ultimate aim is to facilitate the smooth clinical translation of state-of-the-art multi-parametric imaging methods in the modern clinic.

The primary tool utilized for this purpose is a continuously evolving library of in-house C/C++ and MATLAB libraries, which has been developed and validated throughout a list of peer-reviewed publications. In the past, we contributed to large-scale CERN software projects, such as Geant4 and GATE Monte Carlo simulation packages. Furthermore, we are currently designing and validating new libraries for more specific open-source software packages such as the open-source STIR (Software for Tomographic Image Reconstruction) platform and R Statistical Package.

My research activities, during my PhD appointment, in the area of Monte Carlo simulations for Emission Tomography Imaging have decisively helped me envision my current research strategy.

By productively interacting with other equally enthusiastic and highly motivated research partners and collaborators, we aim at innovative and translational methodologies for the enhancement of the quantitative value of nuclear medical imaging to improve its diagnostic and theranostic role in cardiology, oncology and neurology.


On-going research projects

  • “Whole-Body PET/CT and PET/MR Parametric Imaging to enhance atherosclerotic plaque and tumor detectability and quantitation”
    Feb, 2011 – now

Past Research Projects

  • “Generalized Intra- and Inter-Frame Motion Correction for Dynamic PET Brain Imaging”,
    Feb, 2011 – July 2015
  • “3.5D Dynamic PET image reconstruction incorporating kinetics based clusters”,
    March 2011 – March 2013
  • “Implementation of Variance Reduction Techniques for Improvement in Computation Efficiency of GATE Monte Carlo Simulation Package on a Distributed Computing Platform – fastGATE”,
    March 2006 – March 2008
    Scientific and Technological Cooperation between RTD Organizations in Greece and RTD Organizations in U.S.A. In collaboration with Crump Institute for Molecular Imaging at University of California, Los Angeles
  • “Simulation and Modelling of Complicated Biological Processes in Small Animals”,
    Jan. 2006 – 2007
    Scientific and Technological Cooperation between RTD Organizations in Greece and RTD Organizations in Albania. In collaboration with Tirana Polytechnic University
  • “Monte Carlo simulation of a new generation, small field of view and high resolution Positron Emission Tomography (small animal PET)”,
    July 2005 – 2007
    Scientific and Technological Cooperation between RTD Organizations in Greece and RTD Organizations in Spain. In collaboration with Madrid Polytechnic University

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